All the seminars, past and upcoming
Start Monday November 7th at 4pm (CET, Berlin/Paris)
(3 pm London/Lisbon, 10am New-York, 7am San Francisco, 5pm Tel Aviv)
Link to the Zoom conference: https://univ-grenoble-alpes-fr.zoom.us/j/91695622024?pwd=NjhjVXcrTGwrb3lIZThoRGd0WmsxZz09
Link to the YouTube stream: https://www.youtube.com/watch?v=tEErw2MK6lo9
Main Speaker: Amy Buck, co-Head of Institute for the Institute of Immunology & Infection Research, Edinburgh, UK (Link)
Small RNAs in host-pathogen interactions: probing cross species RNA interference
RNA interference pathways play diverse functions in eurkaryotic gene regulation and viruses have evolved to take advantage of these pathways to manipulate the host cell and enable their life cycles. Research by ourselves and others has shown that viruses can do this through direct viral-host RNA-RNA interactions involving the RNA induced silencing complex (RISC). We previously found that murine cytomegalovirus directly interacts with miR-27 through a virus-encoded RNA and this leads to a degradation of miR-27 and de-regulation of its targets. We have extended our biochemical analysis of viral-host interactions to other viruses and found that an RNA virus also directly interacts with miR-27 to sequester this miRNA from its host targets. Given the precedent for RNA-RNA interactions between pathogens and hosts, we have developed approaches to study whether and how extracellular pathogens also directly interact with their hosts using RNA. I will discuss our latest work on RNA and extracellular vesicle trafficking between a gastrointestinal nematode, Heligmosomoides bakeri, and its mouse host where we have found a specific nematode Argonaute protein involved in RNA export.
Short session speaker (8 minutes long):
Jose Roberto Bermudez Barrientos (post doc)
Title: Disentangling sRNA-Seq data to study RNA communication between species
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.